The Art of Crystallization Development -- From Form Screening to a Stable Crystallization Process | C&EN Webinars | Chemical & Engineering News
The Art of Crystallization Development —
From Form Screening to a Stable Crystallization Process

Thursday, September 29, 2011
USA: 11:00 a.m. EDT • 10:00 a.m. CDT • 8:00 a.m. PDT
Europe: 5:00 p.m. Berlin • 4:00 p.m. London

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Overview: The aim of a crystallization process is to produce the optimal form of a solid with all of the desired properties such as particle size, particle shape, bulk density, purity, yield, and residual solvent content. Developing a process to achieve this goal requires multiple steps. This informative C&EN webinar will examine the steps that include:

  • A salt and/or co-crystal screening and characterization to identify the optimal salt or co-crystal.
  • A polymorph and solvate screening of the desired substance to identify, characterize, and determine the thermodynamic relationships of all relevant forms.
  • Arrival at a final selection of optimal form, which is often the thermodynamically stable form at room temperature or a hydrate.

A small-scale (10-250 mL) process is then developed to obtain the selected optimal form in the desired particle size distribution; yield, purity, and other crystallization parameters are optimized at this stage. Often, a seeded crystallization process is required to deliver optimal control. This process is then further scaled up in a kilo-lab, followed by production on a kg-scale in a GMP-facility. Quick communication and efficient know-how transfer between the scientists of the various disciplines assures a very efficient and fast process.

In this webinar, participants will learn:
  • Logical approach to form selection.
  • Examples for form characterization (critical water activity).
  • How to develop a crystallization process.
  • Important parameters of a crystallization process.
  • Required toolbox.
  • Case studies.

Who should attend?
  • Scientists/researchers.
  • Those interested in automated, offline SPE and GC/MS.
  • Lab managers and directors of chemical and pharmaceutical development.

Speakers:
Joel HansonRolf Hilfiker, Ph.D.,
Head of Department of Solid-State Development
Solvias AG




Moderator:
Ann ThayerAnn Thayer
Senior Correspondent
C&EN



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