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_____ Brought to you by Thermo Fischer Scientific _____

The Emerging Role of Cryo-Electron Microscopy in Drug Discovery

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  March 26, 2019

  8:00 a.m. PDT / 11:00 a.m. EDT / 15:00 GMT / 16:00 CET

 

Overview

 

No longer a niche technique, single particle cryo-electron microscopy (cryo-EM), provides a prevailing direction to obtain high-resolution structure information on proteins without crystallization.

This webcast looks at the emerging role of cryo-EM in drug discovery and its application to resolve the structure of challenging targets, such as GPCRs. Experts will share their success in cryo-EM enabled structure-based drug design (e.g. structure-based vaccine design) and the strength of combining cryo-EM with computational chemistry.

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Key Learning Objectives

  • How cryo-EM/single particle analysis (SPA) can be used in structure based drug design
  • The current potential of the cryo-EM/SPA technology
  • The value of cryo-EM in lead optimization
  • Potential of cryo-EM in understanding disease mechanisms/mode of action
  • How cryo-EM/SPA is complementary to other structural biology techniques such as x-ray crystallography and nuclear magnetic resonance (NMR)

Who Should Attend

  • Medicinal Chemists
  • Bio-informaticians
  • Biophysicists
  • Structural Biologists
  • Molecular Modelers
  • Pharmacologists
 

Speakers

Dr. Priyanka Abeyrathne,
Expert Scientist, Structural Biology & Biophysics,
Vaccines GlaxoSmithKline
Dr. Rob Cooke,
SVP, Head of Biomolecular Structure,
Sosei Heptares
 

Moderator

Linda Wang,
Senior Correspondent,
C&EN
 

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