Leave No Peak Unseen: New Developments in Label-Free Detection of Substances without Chromophores
CEN Webinars: Stronger Bonds
Leave No Peak Unseen: New Developments in Label-Free Detection of Substances without Chromophores
Thursday June 18th 2015
USA 11:00am EDT, 8:00 am PDT, 16:00 BST
SPEAKERS
Speaker
Bruce Bailey,
Product Applications Manager,
Thermo Fisher Scientific
 
Speaker
Dave Thomas,
Product and Support Scientist,
Thermo Fisher Scientific
Spacer
MODERATOR
Moderator
Jeff Huber,
Associate Editor,
C&EN
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OVERVIEW

A single HPLC detector is often incapable of revealing the true quality and purity of a critical formulation. Most LC detectors respond more strongly to some analytes than others, and sometimes don't respond at all. For example, UV/Vis absorbance detection is available for those substances that have a chemical structure with a suitable chromophore. However, for compounds that lack a chromophore, an alternate detection technique is necessary. Alternate detection techniques include universal detectors such as refractive index (RI), evaporative light scattering (ELSD), charged aerosol (CAD) or mass spectrometry (MS). When choosing which universal detector to use, what is most desired is the ability to simultaneously quantify a wide range of analytes with good sensitivity and accuracy.

Join this webinar to hear a detailed comparison between the analytical performance of CAD and ELSD with a focus on sensitivity, dynamic range, inter-analyte response, linearity, reproducibility and the effects of mobile phase flow rate. During the webinar, there will be discussion of how these differences in fundamental behavior have a significant impact on analytical performance.

KEY LEARNING OBJECTIVES:

- Detection mechanisms of CAD and ELSD are explained

- Example comparative data provided

- Key applications are highlighted

WHO SHOULD ATTEND
  • • Pharmaceutical Analysts
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  • • BioPharmaceutical Analysts
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  • • HPLC Laboratory Managers
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  • • Analytical Chemists
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