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Nativeomics: Identifying Endogenously Bound Ligands to Membrane Proteins Using Tribrid Mass Spectrometry

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  November 18, 2019

  8:00 a.m. PST, 11:00 a.m. EST, 16:00 GMT, 17:00 CET

 

Overview

 

Small molecule ligands regulate the conformation, stability and function of many membrane proteins. They are sometimes "hinted" in cryo-EM and crystallography studies but cannot be chemically defined. Using the latest advances in Tribrid Mass Spectrometry, we have developed "Nativeomics", a novel top-down method unifying "omics" (lipidomics, proteomics, metabolomics) with native MS analysis, to identify endogenous ligands specifically bound to membrane protein assemblies. By maintaining the link between proteins and binding partners, we can define the lipidome/metabolome in contact with membrane protein assemblies to discover previously unknown complexes, new endogenous ligands and regulators of protein function.

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Key Learning Objectives

  • Nativeomics, a novel top-down method for studying protein complexes
  • Latest advances in High Resolution Tribrid Mass Spectrometry for Structural Analysis of Proteins

Who Should Attend

  • MS practitioners
  • Researchers/ R&D Mangagers
  • Laboratory Managers/ Directors / Supervisors
  • Laboratory Technicians / Operators
  • Structural Biologists
  • Scientists in biopharma engaged in biotherapeutic characterization
 

Speaker

Dr Joseph Gault, Ph.D.
University of Oxford
Junior Research fellow
 

Moderator

Ann Thayer
Contributing Editor
C&EN Media Group
 

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