Methodology for Characterization of Impurities in Crop Protection Products
CEN Webinars: Stronger Bonds
Methodology for Characterization of Impurities in Crop Protection Products
Thursday June 25th 2015
USA 11:00 am EDT, 8:00 am PDT, 16:00 BST
Dr. Peter Hancock, Ph. D.,
Senior Scientific Operations Manager,
Chemical Materials,
Waters Corporation
Dr. Marian Twohig, Ph. D.,
Principal Scientist,
Chemical Materials,
Waters Corporation
Jeff Huber,
Associate Editor,
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The identification and quantification of impurities plays a critical role at all stages of the pesticide development and manufacturing processes, and are essential requirements for the registration of crop protection products. In this webinar, we present a methodology to streamline impurity detection and characterization using chromatographic separations in conjunction with a combination of UV and mass detection for the initial analytical profiling of a commercially available triazole fungicide.

The addition of mass spectrometry as a detection technique adds confidence by providing orthogonal information to UV detection and additional structural information helping the elucidation of impurity unknowns. Further studies with high resolution mass spectrometry, using the efficient workflows found in the UNIFI Scientific Information System, facilitated the identification of relationships between the unknown components and the active ingredient. This case study will demonstrate the value of an analytical methodology that employs UltraPerformance chromatographic separations coupled with mass spectrometry to rationalize structurally related impurities in crop protection products, and serves as a valuable addition to the repertoire of analytical chemists in the agrochemicals industry.


- How the addition of mass detection as a complementary analytical detection technique enhances confidence in compound detection and identification.

- A workflow for impurity identification will be demonstrated using both high resolution liquid chromatography and mass spectrometry orchestrated by comprehensive Informatics software.

  • • Chemists involved with characterization of impurities in crop protection products.
  • • Laboratory managers, scientists and technicians supporting agrochemical synthesis, research, production, formulation and quality testing.
  • • Faculty and students involved in agrochemicals synthesis, research, and testing.
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