_____ Brought to you by Wyatt Technology _____
Characterization of Lipid Nanoparticle Drug Formulations
January 28, 2020
8:00 a.m. PST, 11:00 a.m. EST, 16:00 GMT, 17:00 CET
One of the primary challenges in developing and commercializing novel nanoparticle-based therapies is detailed characterization of the formulation components. FFF-DLS-MALS technology, which couples light scattering and other online detectors to field-flow fractionation, addresses this challenge. This webinar will explore applications of FFF-DLS-MALS to characterize nanoparticle drug- and gene-delivery formulations, to determine high-resolution size distributions, drug loading and release, and particle structure.
The focus of the webinar will be colloidal lipid-based formulations, such as nanoemulsions and liposomes, that can be used to formulate poorly-water-soluble drugs in aqueous preparations to facilitate intravenous administration. FFF-DLS-MALS provides a very useful analytical tool to investigate the behavior of such formulations, even in complex physiological media such as serum. Case studies to be presented include: measurement of detailed liposome size distributions; assessment of drug release and transfer to cell membrane proxies; particle morphology; quantification of co-existing colloidal structures; and stability of the nanocarriers. The relevance of FFF-DLS-MALS to meeting FDA requirements for liposome formulations will be discussed.
Brought to you by:
- The technology and capabilities of AF4 combined with DLS and MALS and additional detection modes
- Applications of FFF-DLS-MALS to characterizing formulations containing colloidal drug or gene carriers such as liposomes and emulsions
- The prospects of FFF for the comprehensive characterization of nano-sized drug carrier systems with respect to drug release and co-existing colloids in physiologically-relevant media
- Pharmaceutical scientists involved in the formulation and characterization of nanoparticle or lipid-based drug formulations.
- Industrial lab managers interested in expanding their range of capabilities for nanoparticle analysis
- Academic researchers exploring nanomedicines for delivering small molecule or gene therapeutics.
Judith Kuntsche, PhD
University of Southern Denmark
Christoph Johann, PhD
Global Product Manager
C&EN Media Group