CEN Webinars: Stronger Bonds

From Mobility to Stability:
Light Scattering Solutions for Formulating Stable Biotherapeutics


Tuesday, May 14, 2013

USA 11:00 a.m. EDT / 10:00 a.m. CDT / 8:00 a.m. PDT / 16:00 BST


Who should attend?

• Formulation biochemists and biophysicists

• Scientists involved in protein or peptide engineering, production or quality control

• Directors / Laboratory Managers supervising biophysical characterization groups


Chris Broomell, Ph.D.
Application Scientist
Wyatt Technology Corporation


Light scattering provides a powerful suite of techniques for biophysical screening and characterization in the pursuit of a stable yet efficacious biotherapeutic formulation. In this webinar we will explore various analytical tools employing multi-angle static light scattering (MALS), dynamic light scattering (DLS,) and electrophoretic mobility phase-analysis light scattering (EM-PALS):

• High-throughput screening (HTS) DLS, performed directly in microwell plates, to qualify buffer conditions for aggregation, colloidal stability, thermal stability and viscosity

• SEC-MALS and FFF-MALS for quantifying aggregates small and large in a stability course study

• EM-PALS for determining net charge

• CG-MALS for characterizing self-association/self-interaction and protein- excipient interactions at moderate to high protein concentration, as well as protein-target binding

Key Learning Objectives:

• Brief introduction to static and dynamic light scattering

• How each of the light scattering techniques: HTS-DLS, SEC-MALS, FFF-MALS, CG-MALS and EM-PALS contributes to different stages in the formulation process, culminating in stable and well-characterized biotherapeutics

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Register FREE at http://tinyurl.com/cbllbkn