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Absolute Molar Mass Analysis of Medical Device and Pharmaceutical Polymers

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  June 18, 2019

  8:00 a.m. PDT, 11:00 a.m. EDT, 16:00 BST, 17:00 CEST

 

Overview

 

Polymers used in medical devices and drug-delivery systems, as active pharmaceutical ingredients, and especially bio-absorbables, invariably require reliable characterization of the molar mass distribution. The types of polymers used in these applications can be difficult to analyze using size exclusion chromatography (SEC) due to limited solubility, interactions with column packings, or high molar mass.

This webinar will provide insight into the methods used for absolute molar mass analysis of modern medical polymers, primarily multi-angle light scattering measurements coupled to size-exclusion chromatography (SEC-MALS). Case studies will be presented to illustrate some of the techniques employed to solve the analytical challenges these materials present.

The unique challenges involved with the analysis of therapeutic polypeptides, resorbable polyesters, and hyaluronic acid will be discussed. Though the theme of the presented case studies is specific, the techniques outlined are applicable to a broad range of SEC analyses.

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Key Learning Objectives

  • Necessity of multi-angle light scattering (MALS) for high-molar-mass samples
  • Advantages and disadvantages of MALS versus conventional column calibration analyses
  • Results fitting for more reproducible calculations of low-molar-mass species
  • The use of hexafluoroisopropanol as a solvent for select sample types
  • Mobile phase modification for resorbable polyesters with carboxylic acid end-groups

Who Should Attend

  • Medical device developers
  • Polymeric drug-delivery system experts
  • Polymer analysts and other scientists interested in learning about SEC-MALS
  • Chromatographers interested in the use of specialty fluorinated solvents for SEC
 

Speakers

Gavin Smith
Chromatography Scientist, SEC Lead
SGS Polymer Solutions Inc.
Jason Todd
Chromatography Laboratory Manager
SGS Polymer Solutions Inc.
 

Moderator

Taylor Hood
Digital Content Producer
C&EN
 

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