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_____ Brought to you by Wyatt Techology _____

Analysis of viral proteins, monoclonal antibodies and their interactions with light scattering



  June 23, 2020

  8:00 a.m. PDT, 11:00 a.m. EDT, 16:00 BST, 17:00 CEST




Characterizing viral proteins and their interactions with receptors and engineered monoclonal antibodies is key to fundamental understanding of how a virus infects cells and ultimately to the successful development of protein-based drugs. Light-scattering based methods provide essential solutions to addressing these questions.

Dynamic light scattering (DLS) offers rapid, low-volume assessment of protein quality and binding. Size-exclusion chromatography coupled to multi-angle light-scattering (SEC-MALS) delivers crucial information regarding protein quality and homogeneity, degree of glycosylation and complex formation. Composition-gradient light scattering (CG-MALS), which does not involve separation, is a label-free method for analyzing binding affinities between molecules in solution, and provides detailed information about the nature of homo- and hetero-oligomers. This webinar will shed light on the theory and technology of light scattering, and how it is used for the biophysical characterization of viral proteins, mAbs and their interactions.

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Key Learning Objectives

  • Light scattering theory and instrumentation
  • Basic biophysical characterization of proteins with light scattering
  • How protein conjugate analysis characterizes hetergeneous glyoproteins
  • Analysis of intermolecular interactions via CG-MALS

Who Should Attend

  • Scientists seeking to expand their knowledge analytical methods for the characterization of biological macro-molecules
  • Biochemists interested in orthogonal methods to SPR, ITC, and fluorescence-based analysis of binding affinities
  • Biopharmaceutical researchers interested in analysis of therapeutic mAbs and target proteins, building off standard HPLC/FPLC


Dr. Felix Gloge
Field Application Scientist,
Wyatt Technology


Catherine Dold
Health & Environment Writer,
C&EN Media Group