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_____ Brought to you by Wyatt Technology _____

Understanding Phase Separation in Hydrogel Microparticles via Complementary Light Scattering and Microscopy Tools



  September 17, 2019

  8:00 a.m. PDT, 11:00 a.m. EDT, 16:00 BST, 17:00 CEST




This webinar will present the use of dynamic light scattering (DLS), electrophoretic light scattering (ELS), and various microscopy methods to understand pH and pH- and temperature-triggered swelling transitions in a unique class of "ultra-low-cross-linked" hydrogel microparticles. An introduction to dynamic light scattering and phase-analysis light scattering will be provided as well.

The complex interplay between thermally-driven polymer phase separation, charge segregation, and nanostructure evolution present a set of particularly difficult characterization challenges that are overcome by employing a suite of complementary yet orthogonal analytical tools. Given the potential utility of this class of materials for a wide range of applications in biotechnology, obtaining a deep level of insight into their properties is of paramount importance when considering efficacy, safety, and overall materials performance.

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Key Learning Objectives

  • Basics of dynamic and electrophoretic light scattering, technology and applications.
  • DLS size analysis of hydrogel microparticles
  • ELS for electrophoretic mobility determination
  • Size and morphology analysis via atomic force microscopy
  • Analysis of micro- and nano- phase separation events occurring in microparticles during volume phase transitions
  • Who Should Attend

    • Researchers interested in exploring DLS/ELS/AFM for soft materials analysis
    • Researchers interested in understanding more about hydrogel microparticles, their characterization, and potential applications


    Professor Andrew Lyon,
    Dean of Fowler School of Engineering,
    Chapman University
    Dr. Jason Lin,
    Application Scientist,
    Wyatt Technology Corporation


    Celia Arnaud,
    Senior Correspondent,