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Drug Delivery

Chemistry In Pictures

TRAP and release

by Brianna Barbu
March 12, 2025
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Most Popular in Pharmaceuticals

 

A structural model of a protein cage.
Credit: Macromol. Rapid Commun.

This sphere may look like a cluster of Froot Loops, but it’s actually the structure of a drug delivery capsule made from 24 ring-shaped translocon-associated protein (TRAP) complexes held together with cobalt, gold, or zinc ions. Created by researchers at Durham University and the Malopolska Centre of Biotechnology, these 22-nm diameter cages are large enough to comfortably tote a couple of proteins—or a couple hundred small drug molecules. The spheres fall apart and release their cargo in acidic environments, such as those found inside tumors (Macromol. Rapid Commun. 2024, DOI: 10.1002/marc.202400712).

Credit: Macromolecular Rapid Communications

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Chemical & Engineering News
ISSN 0009-2347
Copyright © 2025 American Chemical Society

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