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Drug Development

Roche partners with Atea on COVID-19 antiviral

by Ryan Cross
November 8, 2020 | A version of this story appeared in Volume 98, Issue 43
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The structure of AT-527.

Roche will pay Atea Pharmaceuticals $350 million for rights to develop and distribute AT-527, an experimental antiviral treatment, outside the US. Before the COVID-19 pandemic, Atea had begun developing AT-527, a purine nucleotide prodrug, as an oral treatment for infections of hepatitis C virus. The company is now testing the molecule, which interferes with viral RNA polymerase, in a clinical trial of people with mild to moderate COVID-19. Atea also granted Roche rights to manufacture AT-527 worldwide.

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