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Gene Therapy

Biogen to develop zinc finger therapies with Sangamo

by Ryan Cross
March 7, 2020 | A version of this story appeared in Volume 98, Issue 9
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Biogen is paying Sangamo Therapeutics $350 million up front to develop gene therapies for neurological diseases. The deal focuses on Sangamo’s zinc finger protein transcription factors (ZFP-TFs), which dial the expression of genes up or down. The two most advanced programs in the collaboration use ZFP-TFs to decrease levels of tau proteins and α-synuclein proteins, implicated in Alzheimer’s and Parkinson’s disease, respectively. Biogen has exclusive rights to develop Sangamo’s ZFP-TFs for up to 10 additional targets.

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