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Synthesis

Chemistry in Pictures: Crystal light bulb

by Craig Bettenhausen
August 14, 2018

 

LN-crystallightbulb.jpeg

Ashraf Aboelela, a research fellow in the lab of Michael Kelso at the University of Wollongong, is developing analogues of amiloride, a diuretic used to treat high blood pressure and other conditions. The molecule also can interact with several other biological targets. After this particular amiloride derivative was purified, it formed a thin layer lining a round-bottom flask. While Aboelela removed residual solvent under high vacuum, the fluorescent yellow compound expanded within the flask to form fine sheets and filaments that mimicked the look of a vintage light bulb.

Submitted by Ashraf Aboelela, Research Fellow at the School of Chemistry, University of Wollongong

To read the related paper, check out J. Med. Chem. 2018, DOI: 10.1021/acs.jmedchem.8b00838.


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