ADVERTISEMENT
2 /3 FREE ARTICLES LEFT THIS MONTH Remaining
Chemistry matters. Join us to get the news you need.

If you have an ACS member number, please enter it here so we can link this account to your membership. (optional)

ACS values your privacy. By submitting your information, you are gaining access to C&EN and subscribing to our weekly newsletter. We use the information you provide to make your reading experience better, and we will never sell your data to third party members.

ENJOY UNLIMITED ACCES TO C&EN

Process Chemistry

Chemistry in Pictures: Diazo rainbow

by Manny Morone
July 18, 2019

20190718lnp20-diazo.jpg
Credit: Eric Levesque

What you’re looking at is not one, but five reactions running through the same flow reactor. While studying at the Université de Montréal in the lab of André B. Charette, Eric Levesque designed continuous-flow-synthesis systems similar to this one. This work focused on making diazo compounds, which are synthetically useful yet hard-to-handle molecules. Because flow reactions bring only small amounts of starting materials into contact at once, they have the potential to be safer and thus can be scaled up for industry. Each color of hosing in this flow reactor represents a different reaction product being made sequentially in the tubing (Ph is phenyl):

PhC(N2)CO2C2H5 (yellow)

PhC(N2)CF3 (light orange)

PhC(N2)H (dark orange)

((4-CH3)Ph)C(N2)H (light pink)

Ph2CN2 (dark pink).

Submitted by Eric Levesque. Read the paper: Angew. Chem., Int. Ed. 2017, 10.1002/anie.201608444.

Do science. Take pictures. Win money. Enter our photo contest here.

Related C&EN Content:

Chemists hand off reaction optimization to automated ‘plug and play’ flow system

Iterative Flow Borylations Pump Out Complex Molecules

Organometallic flow reaction reaches industrial scale.

X

Article:

This article has been sent to the following recipient:

Leave A Comment

*Required to comment