Issue Date: November 19, 2007
pCEL-X is software for simulation and refinement of permeability data from Caco-2, a drug transport model, and parallel artificial membrane permeability (PAMPA) determinations. The software uses nonlinear regression to tease out passive, paracellular, carrier-mediated, active-uptake, and efflux effects from pH-dependent data. It predicts permeability coefficients from a comprehensive internal database of Caco-2 and PAMPA measurements, Abraham descriptors, and structural information. The software is PC-based and is compatible with Windows. pION,
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