Volume 85 Issue 51 | p. 25 | Concentrates
Issue Date: December 17, 2007

Copper-Templated Coupling

Department: Science & Technology
News Channels: JACS In C&EN

In 2000, Jiri Srogl and Lanny S. Liebeskind of Emory University reported a unique coupling of thiol esters with boronic acids to produce ketones. That reaction, mediated by a palladium catalyst and a stoichiometric copper cocatalyst, operates at neutral pH and in the absence of oxygen to protect sensitive functional groups. Srogl, Liebeskind, and Janette M. Villalobos have now determined that the same reaction can be carried out under aerobic conditions without a . . .

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