Issue Date: December 17, 2007
A new biological chlorination pathway has been found that is distinctly different from previously known routes. Bradley S. Moore of the University of California, San Diego, and coworkers have discovered and characterized the chlorinase SalL, an enzyme that catalyzes the addition of chlorine to a precursor of salinosporamide A (Nat. Chem. Biol., DOI: 10.1038/nchembio.2007.56). This natural product from a marine bacterium has anticancer activity and is currently in Phase I clinical trials. Removing chlorine . . .
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