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Web Date: October 18, 2007

Copper-Free Click Chemistry

Reagent for labeling biomolecules eliminates need for toxic metal catalyst
Department: Science & Technology | Collection: Life Sciences
News Channels: Biological SCENE

A new reagent developed by chemistry professor Carolyn R. Bertozzi and coworkers at the University of California, Berkeley, eliminates the toxicity usually associated with a rapid and irreversible reaction strategy commonly known as "click chemistry" (Proc. Natl. Acad. Sci. USA, DOI: 10.1072/pnas.0707090104). This tweak to remove copper catalysts makes the reaction, azide-alkyne cycloaddition, biologically friendly and thus useful for labeling biomolecules in cells.

The reagent helps Bertozzi and her team . . .

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