Issue Date: January 12, 2009
Ribosome Has A Third Fidelity Trick Up Its Sleeve
The high accuracy of ribosomal protein synthesis was believed to rely on the fidelity of two key biosynthetic steps, but a research team has found that a previously unknown step is a third important contributor to the fidelity of the process (Nature 2009, 457, 161). The two known steps on which mistake-free protein synthesis depends are the enzymatic addition of correct amino acids to each of the amino acid-specific transfer RNAs and the ribosome's selection . . .
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