Volume 87 Issue 25 | p. 34 | Concentrates
Issue Date: June 22, 2009

Fluorescent Tag Takes The Wheel

Fluorescein study shows that presumed nonreactive labels can sometimes control the destination of bioconjugates
Department: Science & Technology
News Channels: JACS In C&EN
Keywords: fluorescent labeling, ruthenium complex, cell-penetrating peptide

Scientists usually consider fluorescent labels on biomolecule delivery vehicles to be passengers along for the ride. But in some cases, those labels might actually be in the driver's seat. Caltech's Jacqueline K. Barton and Cindy A. Puckett have found that a ruthenium complex conjugated to the cell-penetrating peptide octaarginine displays different cellular uptake behavior when it is tagged with fluorescein (J. Am. Chem. Soc., DOI: . . .

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