Issue Date: January 19, 2009
New Peptide Dissociation Method For Mass Spec
Analysis of peptides in proteomics experiments requires the use of dissociation methods that break the peptides into smaller pieces to determine the amino acid sequence. Gavin E. Reid and coworkers of Michigan State University describe a new dissociation method, called femtosecond laser-induced ionization/dissociation (fs-LID), that overcomes some of the limitations of other dissociation methods (J. Am. Chem. Soc., DOI: 10.1021/ja8089119). In fs-LID, ultrashort laser pulses (<35 femtosecond) deposit sufficient . . .
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