MS Proteomics On Firmer Footing | August 10, 2009 Issue - Vol. 87 Issue 32 | Chemical & Engineering News
Volume 87 Issue 32 | pp. 36-37
Issue Date: August 10, 2009

MS Proteomics On Firmer Footing

Multilab studies assess performance in mass spectrometry-based proteomics experiments
Department: Science & Technology
Keywords: proteomics, HUPO, mass spectrometry, multiple-reaction monitoring, CPTAC, National Cancer Institute

Despite the increasing popularity of mass spectrometry for both discovery-driven and quantitative proteomics, doubts have persisted about the reproducibility of the measurements. Those doubts must be put to rest before such methods will be widely accepted for identification, verification, and validation of protein biomarkers of disease.

Two recent multilaboratory studies suggest that the outlook for mass spectrometry-based proteomics is promising, although trouble spots remain.

In the first study, sponsored by the Human Proteome . . .

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