Issue Date: May 24, 2010
Molecules Impede HIV Replication By Design
Belgian scientists have designed a class of small molecules that inhibit HIV replication by blocking the virus’s ability to hijack the DNA of host cells (Nat. Chem. Biol., DOI: 10.1038/nchembio.370). The host cellular protein LEDGF/p75 is critical to HIV’s replication. This protein tethers the viral integrase enzyme to a cell’s chromosomes as HIV invades a host cell. Zeger Debyser of Catholic University of Leuven and coworkers developed a series of . . .
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