Issue Date: July 26, 2010
Another Take On Platinum Cancer Drugs
The recent article “Platinum Drugs Take Their Toll” summarized the lack of success in bringing new platinum anticancer drugs to the clinic (C&EN, June 28, page 24). Although the process to advance or terminate a new drug candidate is quite complex, a few points concerning drug discovery in the platinum world are worth noting.
Forty years ago, Professor Barnett Rosenberg, the discoverer of the anticancer properties of cisplatin, roughly outlined the structure-activity relationships . . .
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