Issue Date: August 2, 2010
Mass Tags Quantify Glycosylation
Researchers using a new mass-tagging strategy have found a way to quantify the stoichiometry of O-GlcNAc glycosylation in proteins (Nat. Chem. Biol., DOI: 10.1038/nchembio.412). In this type of posttranslational modification, which plays a role in many biological processes, the sugar N-acetyl-D-glucosamine is added to serine or threonine residues. Because the modification is labile and occurs at low levels, it has been difficult to quantify. Linda C. Hsieh-Wilson of California Institute of . . .
You Do Not Have Access to C&EN Protected Content.
- Chemical & Engineering News
- ISSN 0009-2347
- Copyright © American Chemical Society