Mass Tags Quantify Glycosylation | August 2, 2010 Issue - Vol. 88 Issue 31 | Chemical & Engineering News
 
 
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Volume 88 Issue 31 | p. 37 | Concentrates
Issue Date: August 2, 2010

Mass Tags Quantify Glycosylation

Researchers have found a way to determine the stoichiometry of O-GlcNAc glycosylation in proteins
Department: Science & Technology
Keywords: protein, glycosylation

Researchers using a new mass-tagging strategy have found a way to quantify the stoichiometry of O-GlcNAc glycosylation in proteins (Nat. Chem. Biol., DOI: 10.1038/nchembio.412). In this type of posttranslational modification, which plays a role in many biological processes, the sugar N-acetyl-D-glucosamine is added to serine or threonine residues. Because the modification is labile and occurs at low levels, it has been difficult to quantify. Linda C. Hsieh-Wilson of California Institute of . . .

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