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Volume 88 Issue 45 | p. 49 | Concentrates
Issue Date: November 8, 2010

Amyloid Fibrils Grow Asymmetrically

Structural models’ predictions that amyloid fibrils grow symmetrically at both ends is only 20% correct
Department: Science & Technology
Keywords: Alzheimer's disease, unidirectional growth

Structural models have predicted that amyloid fibrils, which are associated with and may help cause conditions such as Alzheimer’s disease, grow symmetrically at both ends. Caryn L. Heldt, Shuqi Zhang, and Georges Belfort at Rensselaer Polytechnic Institute have put those models to the test and found them wanting (Proteins: Struct., Funct., Bioinf., DOI: 10.1002/prot.22861). The researchers attached different fluorescent dyes to the protein insulin, which forms amyloid, and to insulin-based fibrils. . . .

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