Volume 89 Issue 44 | pp. 36-37
Issue Date: October 31, 2011 | Web Date: October 30, 2011

Bruce Roth Looks Ahead

As Lipitor leaps off the patent cliff, its inventor assesses the state of the drug industry
Department: Science & Technology, Business
Keywords: Medicinal chemistry, drug discovery, patent cliff, Lipitor, generic drugs

Bruce Roth was just 31 years old when he first made atorvastatin, a small molecule designed to cut high cholesterol. Medicinal chemists know the rest of the story. Roth went on to scale the management ranks in the pharmaceutical industry, today serving as vice president of discovery chemistry at Genentech. And his most famous handiwork, better known by its brand name Lipitor, became the biggest drug in history, pulling in more . . .

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