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Web Date: August 12, 2011

Meals Modify Proteins

Proteomics: Levels of protein acetylation may change in response to feasting or fasting
Department: Science & Technology
Keywords: metabolism, acetylation, MIMS, mass spectrometry

After a good meal, our bodies relish burning carbohydrates; By contrast, fasting triggers them to favor using stored fats for energy. Scientists think that defects in this tightly regulated system may underlie diseases such as diabetes, but they don’t understand the molecular mechanisms at play. Now researchers report that tissues may use a particular protein modification, acetylation, to pick their energy source (J. Proteome Res., DOI: 10.1021/pr200313x).

A few tissues in the body, such . . .

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