Issue Date: March 26, 2012
Indole Triggers Bacterial Persistence
Bacterial persisters—dormant cells with a high tolerance for antibiotic treatment—are prime culprits in chronic and recurrent infections. James J. Collins and coworkers at Boston University show that indole-based bacterial communication plays a key role in increasing bacterial persistence (Nat. Chem. Biol., DOI: 10.1038/nchembio.915). They incubated cultures of Escherichia coli with physiological levels of indole for one hour and then treated the cultures with high levels of . . .
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