Common Antibiotic Mechanism Shown | April 23, 2012 Issue - Vol. 90 Issue 17 | Chemical & Engineering News
Volume 90 Issue 17 | p. 6 | News of The Week
Issue Date: April 23, 2012

Common Antibiotic Mechanism Shown

Microbiology: Antibiotics kill bacteria by oxidizing guanine nucleotides
Department: Science & Technology
News Channels: Biological SCENE
Keywords: Antibiotics, bacteria, DNA damage, hydroxyl radicals, 8-oxoguanine

Guanine oxidation is at the heart of the cell-killing abilities of many common antibiotics, biologists at MIT and Boston University report (Science, DOI: 10.1126/science.1219192). The findings, if confirmed, could improve scientists’ understanding of the way existing antibiotics actually work.

Previously, James J. Collins and coworkers at Boston University reported that diverse antibiotics with different targets have a common cell-killing mechanism (C&EN, . . .

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