Issue Date: April 30, 2012
Sequencing An Important Epigenetic Mark
Because access to DNA is tightly controlled, hair doesn’t grow on bone and toenails don’t appear in the spleen. Control comes from a system that includes chemical modifications to DNA bases, or epigenetic marks, that ensure the right genes are expressed in the right place at the right time. Two widely known chemical modifications are 5-hydroxymethylcytosine (5hmC) and 5-methylcytosine (5mC). What they do can now be better understood with the first tool to measure, with . . .
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