Sequencing An Important Epigenetic Mark | April 30, 2012 Issue - Vol. 90 Issue 18 | Chemical & Engineering News
Volume 90 Issue 18 | p. 8 | News of The Week
Issue Date: April 30, 2012

Sequencing An Important Epigenetic Mark

Chemical Biology: Technique locates modified cytosines in genomic DNA with single-base resolution
Department: Science & Technology | Collection: Life Sciences
News Channels: Biological SCENE, Analytical SCENE
Keywords: 5-hydroxymethylcytosine, epigenetics

Because access to DNA is tightly controlled, hair doesn’t grow on bone and toenails don’t appear in the spleen. Control comes from a system that includes chemical modifications to DNA bases, or epigenetic marks, that ensure the right genes are expressed in the right place at the right time. Two widely known chemical modifications are 5-hydroxymethyl­cytosine (5hmC) and 5-methylcytosine (5mC). What they do can now be better understood with the first tool to measure, with . . .

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