Issue Date: May 28, 2012
New Way To Modify DNA
Zinc finger nickases are the new kids on the block in the DNA-modification neighborhood. This class of DNA change agents could supplement or even supplant the more established zinc finger nucleases for some research and therapeutic applications, scientists say—but only if they can be improved. Right now that is a big “if.”
Zinc finger nucleases are synthetic proteins that are widely used to modify genes by making site-selective, double-strand breaks in genomic DNA. But they . . .
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