Volume 90 Issue 45 | pp. 32-35
Issue Date: November 5, 2012

Cross-Linking Mass Spectrometry Gets Easier

Improved reagents and data analysis tools extend the method’s reach
Department: Science & Technology | Collection: Life Sciences
News Channels: Analytical SCENE, Biological SCENE
Keywords: cross-linking, mass spectrometry, proteins, structural biology

When Bradford W. Gibson started using chemical cross-linking mass spectrometry more than a decade ago to map the structure of proteins, he knew there would be challenges in both the chemistry and the data analysis.

Starting in the late 1990s, Gibson, then at the University of California, San Francisco, was one of the first mass spectrometrists to use chemical cross-linking to provide distance constraints for structural biology. The cross-linking community has . . .

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