Issue Date: November 19, 2012
To Tell Substrates Apart, Enzyme Switches Reactions
To distinguish two substrates that differ by just one atom, a bacterial enzyme takes an unusual tack, chemists report (Proc. Natl. Acad. Sci. USA, DOI: 10.1073/pnas.1212591109). The enzyme, a thioesterase, subjects the two compounds to different reaction pathways, in contrast to the typical strategy of relying on subtle differences in binding. The work could hold broader lessons for biocatalysis. In the course of forging carbon-fluorine bonds, the microbe . . .
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