Web Date: March 29, 2012
New Class Of Superbases
Cyclopropenimines can serve as highly effective “superbases” for enantioselective organocatalysis, researchers have discovered (J. Am. Chem. Soc., DOI: 10.1021/ja3015764). The findings could lead to easier and faster syntheses of novel chiral compounds for drug discovery and other applications.
In recent years, researchers have developed several types of organic bases to catalyze enantioselective proton-transfer reactions and yield optically enriched products. Most work has focused on chiral amidines and guanidines, but these species have limited . . .
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