Issue Date: March 17, 2014 | Web Date: March 14, 2014
Reports Make Progress In Transforming C–H Bonds Into Druglike Motifs
Carbon-hydrogen bonds are ubiquitous, and chemists would love to transform them at will into entry points to materials or drugs.
Despite great strides, that goal is far from a reality.
A pair of reports now furthers the C–H bond transformation field by taking advantage of weak coordination to palladium catalysts. The chemistry comes from Jin-Quan Yu and coworkers at Scripps Research Institute, La Jolla, Calif.
They describe a tactic for making electron-rich . . .
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