Reports Make Progress In Transforming C–H Bonds Into Druglike Motifs | March 17, 2014 Issue - Vol. 92 Issue 11 | Chemical & Engineering News
 
 
5
Facebook
Volume 92 Issue 11 | p. 5 | News of The Week
Issue Date: March 17, 2014 | Web Date: March 14, 2014

Reports Make Progress In Transforming C–H Bonds Into Druglike Motifs

Organic Chemistry: Palladium-catalyzed routes build unnatural amino acids and meta-substituted aromatic rings
Department: Science & Technology
News Channels: Organic SCENE, Materials SCENE, Biological SCENE
Keywords: catalysis, palladium, organometallic chemistry, meta-substitution, amino acids

Carbon-hydrogen bonds are ubiquitous, and chemists would love to transform them at will into entry points to materials or drugs.

Despite great strides, that goal is far from a reality.

A pair of reports now furthers the C–H bond transformation field by taking advantage of weak coordination to palladium catalysts. The chemistry comes from Jin-Quan Yu and coworkers at Scripps Research Institute, La Jolla, Calif.

They describe a tactic for making electron-rich . . .

You Do Not Have Access to C&EN Protected Content.



 
Chemical & Engineering News
ISSN 0009-2347
Copyright © American Chemical Society