Volume 92 Issue 16 | p. 36
Issue Date: April 21, 2014

Tackling Enzyme Catalysis One Piece At A Time

Protein design strategy focuses on one aspect of catalysis, such as active-site nucleophilicity, at a time
Department: Science & Technology | Collection: Life Sciences
News Channels: Biological SCENE
Keywords: protein design, computational design

Enzyme design has been a mixed bag. The strategy has generated excitement because it has yielded new enzymes that don’t exist in nature. But it has also led to disappointment because those enzymes have fallen far short of the activity of natural enzymes.

Breaking free of nature’s limited enzymatic tool kit could aid the synthesis of biofuels, pharmaceuticals, and other chemicals. To create new enzymes, researchers design the enzymes computationally, produce them in bacteria, and . . .

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