Improved Route To Chiral Amines | September 1, 2014 Issue - Vol. 92 Issue 35 | Chemical & Engineering News
Volume 92 Issue 35 | p. 13 | News of The Week
Issue Date: September 1, 2014

Improved Route To Chiral Amines

Biocatalysis: Amine donor eliminates by-product inhibition in ω-transaminase-based synthesis
Department: Science & Technology
News Channels: Organic SCENE, Biological SCENE
Keywords: ω-transaminase, chiral amines, biocatalysis

A new reagent for ω-transaminase-catalyzed reactions could make it easier to convert ketones to chiral amines in research labs, and with additional development, the reaction might have commercial applications as well.

Many drugs and bioactive natural products feature chiral amines. One class of enzymes researchers use to synthesize them are the ω-transaminases, biocatalysts that convert prochiral ketones to corresponding optically pure amines. The reactions require an amine donor to contribute the amine group that appears . . .

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