Issue Date: September 22, 2014
Adding Fluorine Helps Ailing Antibiotic
A strategically placed fluorine today could keep antibiotic resistance at bay. Aminoglycosides are a class of antibiotics that have traditionally been useful against infections in patients with severe burns or cystic fibrosis. Antibiotic-resistant bacteria have emerged, however, carrying an arsenal of aminoglycoside-inactivating enzymes. One approach to counter the enzymes has been to remove certain aminoglycoside hydroxyl groups. But that change can make the drugs toxic to the kidneys. Stephen Hanessian and colleagues . . .
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- Chemical & Engineering News
- ISSN 0009-2347
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