Issue Date: February 3, 2014 | Web Date: January 30, 2014
Enzyme Makes Tough-To-Construct C–N Bonds
The ability to add nitrogen-containing functional groups to unactivated aliphatic carbon atoms is a challenge for synthetic chemists. The search for enzymes to catalyze such reactions has likewise come up empty-handed. That luck, however, might be about to change.
Chemists at Pennsylvania State University have discovered that an enzyme that usually adds chloride ions to aliphatic carbons can be made to add nitrite or azide ions instead (Nat. Chem. Biol. 2014, DOI: . . .
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