Directed Evolution Keeps Pace | February 10, 2014 Issue - Vol. 92 Issue 6 | Chemical & Engineering News
 
 
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Volume 92 Issue 6 | p. 8 | News of The Week
Issue Date: February 10, 2014

Directed Evolution Keeps Pace

Chemical Biology: Stringency modulation and negative selection in phage-assisted continuous evolution lead to better outcomes
Department: Science & Technology
News Channels: Biological SCENE
Keywords: directed evolution, proteins, selection, bacteriophage

A technique that enables proteins to be evolved in the lab in a continuous manner without user intervention has proven useful in creating proteins with new properties. Now, the researchers who devised the technique have added capabilities that expand the method’s utility.

Phage-assisted continuous evolution (PACE), first developed in 2011 by David R. Liu and coworkers at Harvard University, harnesses the rapid life cycle of bacteria-infecting viruses called bacteriophages to enable rapid . . .

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