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Web Date: December 10, 2014

Silencing Genes In Bacteria With The Help Of Their Neighbors

Method represses specific genes in bacteria by exploiting natural mode of microbial gene transfer
Department: Science & Technology | Collection: Life Sciences
News Channels: Biological SCENE
Keywords: synthetic biology, antibacterial therapy, CRISPR, gene silencing

Broad-spectrum antibiotics have been lifesavers for decades, but their lack of selectivity can cause some problems. The drugs not only wipe out pathogenic bacteria, but also can kill beneficial ones. And widespread use of the antibiotics hastens the spread of resistance genes. Now a research team reports a synthetic biology method that could target problematic bacteria through a natural gene-swapping mechanism used by the microbes (ACS Synth. Biol. 2014, DOI: 10.1021/sb500036q).

The work . . .

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