Re-Creative Successes: Tales of ancient recipes being carried out in modern-day laboratories

Killing MRSA, Anglo Saxon-style

Once upon a time, a microbiologist with a penchant for ancient cultures met an English scholar with a love of ancient medicinal texts at an Old Norse literature reading group. They decided to resurrect a 1,000-year-old Anglo-Saxon recipe for curing eye infections. To their surprise and delight, the pair—along with other researchers at England’s University of Nottingham—found that their re-created concoction kills the hospital superbug MRSA, or methicillin-resistant Staphylococcus aureus. The recipe primarily called for familiar foodstuffs, such as garlic, onion, and wine, as well as some more peculiar ingredients, such as bile from an ox. After stewing for nine days, the mixture the team created killed MRSA just as well as vancomycin, a modern antibiotic. Of the many recipes found in the ancient “Bald’s Leechbook,” the one that Christina Lee—the English scholar—and Freya Harrison—the microbiologist—zeroed in on was for styes. That’s because these eye formations are commonly caused by S. aureus, a pathogen studied by Harrison and her adviser, Steve Diggle, at the University of Nottingham. The team is now looking for pharmacologists and chemists to pinpoint the active ingredient or ingredients in the mixture. “At the end of the day, nobody’s coming out with new antibiotics, so maybe old texts are a good starting point,” Diggle says.

The Secret To Success: Contamination

Many attempts to re-create historical experiments initially fail for a variety of reasons, including challenges sourcing ingredients and difficulties inherent in following centuries-old directions. Yet when Lawrence Principe, a historian of alchemy and chemist at Johns Hopkins University, set out to make glass of antimony, a yellow glass touted as a medicine, he thought it wouldn’t be too difficult. “Alchemists wrote that this was rather trivial to make,” he says. “But I wasn’t even close.” Morose-looking gray lumps sat in his vessel instead of transparent golden glass. Disheartened but not defeated, Principe wondered about the source of stibnite—an antimony ore—used in the recipe he was following. It turns out that in Eastern Europe, where the recipe had originated, stibnite contains 1–3% quartz, or silica. When Principe added silica to his concoction, “lo and behold it worked just fine,” he says. An even more extreme case of impurities playing a key role in the success of alchemical recipes is the so-called Bologna stone. Principe determined that to make this artificial phosphorescent material—the first of its kind—one must literally source the principal ingredient, the mineral barite, from Bologna in Italy. “Barite found just outside the city of Bologna has absolutely no iron, which is a luminescence poison, and it also contains a trace amount of copper,” Principe says. The copper is required for making the stone phosphoresce. Principe only managed to successfully re-create the recipe when he followed centuries-old directions for tracking down the barite ore in fields just outside Bologna.