Volume 93 Issue 37 | p. 26 | Concentrates
Issue Date: September 21, 2015

New Polymer Coat Gives Protein Immunity

Biotechnology: Zwitterionic polymer may reduce immunogenicity and improve stability of biotherapeutics
Department: Science & Technology | Collection: Life Sciences
News Channels: Biological SCENE
Keywords: therapeutic protein, biotherapy, immunology, gel, polymer

Proteins can be valuable therapeutic drugs, but they often cause immune reactions. The gold-standard strategy to diminish those negative effects is to coat proteins with polyethylene glycol (PEG) chains. For many patients, however, the immune system still reacts to form anti-PEG antibodies, which can lead to diminished drug efficacy and allergic reactions. University of Washington, Seattle, researchers led by Shaoyi Jiang have therefore turned to polycarboxybetaine (PCB) as an alternative (Proc. Natl. . . .

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