Issue Date: September 21, 2015
New Polymer Coat Gives Protein Immunity
Proteins can be valuable therapeutic drugs, but they often cause immune reactions. The gold-standard strategy to diminish those negative effects is to coat proteins with polyethylene glycol (PEG) chains. For many patients, however, the immune system still reacts to form anti-PEG antibodies, which can lead to diminished drug efficacy and allergic reactions. University of Washington, Seattle, researchers led by Shaoyi Jiang have therefore turned to polycarboxybetaine (PCB) as an alternative (Proc. Natl. . . .
To view the rest of this content, please log in with your ACS ID.
- Chemical & Engineering News
- ISSN 0009-2347
- Copyright © American Chemical Society