Volume 93 Issue 7 | p. 26 | Concentrates
Issue Date: February 16, 2015

Chemists Design Insulin That’s Responsive To Blood Glucose Levels

Phenylboronic acid groups on the designer compound bind glucose, switch on insulin
Department: Science & Technology
News Channels: Biological SCENE, Organic SCENE
Keywords: diabetes, insulin, glucose sensing

For people with type 1 diabetes, insulin injections can keep blood glucose levels down. To make the injection process easier for patients, chemists have been tweaking insulin’s composition. One long-lasting insulin formulation, for example, contains a hydrophobic alkyl chain that increases circulation half-life by binding to albumin and other proteins. The activity of that long-lasting insulin, however, is independent of the amount of glucose in the blood, so changes in blood sugar are not always . . .

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