Issue Date: March 28, 2016 | Web Date: March 24, 2016
Chemists cut in half the number of steps needed to synthesize phorbol
For the first time, chemists have completed an enantioselective total synthesis of the complex natural product (+)-phorbol. And they did it with a route that requires only 19 steps. That’s a dramatic cut in chemical transformations from previous approaches, which took 40 to 52 steps to make a racemic mixture of the compound.
Since its discovery more than 80 years ago, densely functionalized, polycyclic phorbol has intrigued both chemists and biologists. One source of phorbol . . .
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