• CORRECTION: This story was updated on April 21, 2016, to clarify that the method described was not the first radical-based route to chiral quaternary carbon centers. The method is the first route involving radical conjugate addition, not the first radical route of any kind.
Volume 94 Issue 16 | p. 9 | News of The Week
Issue Date: April 18, 2016 | Web Date: April 14, 2016

New radical route to chiral quaternary carbons reported

New reaction could provide an easier path to the important stereocenters
Department: Science & Technology
News Channels: Organic SCENE
Keywords: catalysis, quaternary, radical conjugate addition, radical, imine, photocatalyst, organocatalyst

Many natural products, pharmaceuticals, and other biologically active molecules feature chiral carbon atoms attached to four other carbons. Chemists can synthesize these quaternary stereocenters using organometallic reagents that add carbon groups to conjugated carbonyl compounds. These reagents, however, are expensive and hard to generate, can cause problematic side reactions, and don’t always work well at crowded carbon centers.

Now researchers report a new radical route to quaternary carbon stereocenters, offering a possibly easier way to . . .

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