Volume 94 Issue 16 | p. 7 | News of The Week
Issue Date: April 18, 2016 | Web Date: April 14, 2016

New close-up views of the nuclear pore complex

Two studies bring the architecture of the cell’s mega transport machinery into better focus
Department: Science & Technology
News Channels: Analytical SCENE, Biological SCENE
Keywords: structural biology, nuclear pore complex, cryo-electron microscopy, X-ray crystallography

As gatekeeper of the cell’s nucleus, the nuclear pore complex (NPC) controls the shuttling of thousands of different proteins, RNA molecules, and nutrients between the nucleus and surrounding cytoplasm. Built from more than 30 types of nucleoporin proteins, and with a mass of more than 100 million daltons and a width of 1,000 Å, the NPC’s gargantuan, membrane-embedded structure has long stymied structural biologists.

Two research teams working indepen­dently have now reported the overall architecture . . .

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ISSN 0009-2347
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