Volume 94 Issue 19 | p. 9 | Concentrates
Issue Date: May 9, 2016

Agent uses quorum sensing to help kill resistant bacteria

Natural product analog boosts power of existing antibiotics and has better drug properties than parent compound
Department: Science & Technology
News Channels: Biological SCENE
Keywords: antibiotics

The superbug methicillin-resistant Staphylococcusaureus (MRSA) is a leading cause of hospital infections. Serge Van Calenbergh of Ghent University and coworkers have now developed a potentiator that helps overcome MRSA resistance to antibiotics by disrupting quorum sensing (Angew. Chem. Int. Ed. 2016, DOI: 10.1002/anie.201601973). Potentiators are agents that boost the sensitivity of microbes to existing drugs, and . . .

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